Enantioselective synthesis of almorexant via iridium-catalysed intramolecular allylic amidation.
نویسندگان
چکیده
An enantioselective synthesis of almorexant, a potent antagonist of human orexin receptors, is presented. The chiral tetrahydroisoquinoline core structure was prepared via iridium-catalysed asymmetric intramolecular allylic amidation. Further key catalytic steps of the synthesis include an oxidative Heck reaction at room temperature and a hydrazine-mediated organocatalysed reduction.
منابع مشابه
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 11 27 شماره
صفحات -
تاریخ انتشار 2013